期刊
COMPOSITES PART B-ENGINEERING
卷 178, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.compositesb.2019.107521
关键词
Metal-matrix composites (MMCs); Photothermal; Nano-structures; Surface properties; Magnetic properties
资金
- National Natural Science Foundation of China [81801848]
- Sichuan Science and Technology Program [2017FZ0046, 2018JZ0026, 2019YJ0554]
- International Science and Technology Center Funding of Chengdu [2017-GH02-00025-HZ]
- Deyang Science and Technology Program [19YXKJ0009]
- State Key Laboratory of Polymer Materials Engineering [sklpme2019-2-05]
- Hong Kong Scholar Program
- Australian Research Council
In this study, we develop polyethylene glycol (PEG) modified nanocomposites, which structurally constitute graphene oxide (GO) and cobalt nanoparticles (CoNPs), called as the CoNPs-GO-PEG nanocomposites. These CoNPs-GO-PEG nanocomposites show better outcomes and less side effects when eliminating tumor cells. After a series of comprehensive characterizations, the CoNPs-GO-PEG nanocomposites are proved to possess pleasing targeting ability and unique drug release behavior, indicating that the concentration of the drug delivered by CoNPs-GO-PEG in the tumor site is much higher than that in the normal tissue, and concerning the favorable biocompatibility of CoNPs-GO-PEG nanocomposites, less harm is caused to normal tissue compared to traditional chemotherapy. Furthermore, because of the satisfactory photothermal effect and favorable drug release behavior of the material, the CoNPs-GO-PEG are able to eradicate most of the tumor cells (99%) through synergistic chemo-photothermal therapy in vitro. So far, our study has demonstrated an inspiring potential for the CoNPs-GO-PEG nanocomposites to act as a favorable targeting multifunctional agent in cancer therapy.
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