期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
卷 33, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbd.2019.100649
关键词
Mongolian horse; Skeletal muscle; Fiber type; Transcriptome; Alternative splicing
资金
- National Natural Science Foundation of China [31960657, 31860636, 31902188, 31360538, 31472070]
- National Key Research and Development Program of China [2017YFE0108700]
- Natural Science Foundation of Inner Mongolia Major Project [2017ZD06, 2019MS03064]
- project of special funds for landmark achievements of College of Animal Science, Inner Mongolia Agricultural University [BZCG201901]
- project of talent cultivation project of double -first-class discipline innovation team construction of Inner Mongolia Agricultural University [NDSC2018-05]
- project of special funds for subsidies after scientific and technological innovation of herbivorous livestock of College of Animal Science, Inner Mongolia Agricultural University [QN201909]
- project of special funds for transforming scientific and technological achievements breeding (cultivating) for new varieties of animals and plants of Inner Mongolia Agricultural University [YZGC2017001]
- startup project for High-level Talents of Inner Mongolia Agricultural University [NDGCC2016-01]
Skeletal muscle is the largest organ system in the mammalian body and plays a key role in locomotion of horses. Fast and slow muscle fibers have different abilities and functions to adapt to exercises. To investigate the RNA and miRNA expression profiles in the muscles with different muscle fiber compositions on Mongolian horses. We examined the muscle fiber type population and produced deep RNA sequencing for different parts of skeletal muscles. And chose two of them with the highest difference in fast and slow muscle fiber population (splenius and gluteus medius) for comparing the gene expression profile of slow and fast muscle fiber types. We identified a total of 275 differentially expressed genes (DEGs), and 11 differentially expressed miRNAs (DEmiRs). In addition, target gene prediction and alternative splicing analysis were also performed. Significant correlations were found between the differentially expressed gene, miRNAs, and alternative splicing events. The result indicated that differentially expressed muscle-specific genes and target genes of miRNAs might co-regulating the performance of slow and fast muscle fiber types in Mongolian horses.
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