期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 186, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2019.110727
关键词
Antibacterial; Wounding healing; Gold; Silver; Nanoplates
资金
- National Key Research and Development Program of China [2018YFF0215500, 2017YFA0205400]
- National Natural Science Foundation of China [51773089, 51973091]
- Natural Science Foundation of Jiangsu Province [BK20181204]
- Science and Technology R&D Fund of Shenzhen City [JCYJ20170818110736342]
Although silver nanoparticles are considered as promising antibacterial agents because of their antibacterial activity, the acute cytotoxicity of Ag+ released from Ag nanoparticles restricts their potential practical applications. Herein, porous Ag@Au nanoplates, which could balance the Ag+ release and the toxicity of Ag naoparticles, were fabricated by stepwise seed-mediated growth and oxidation. Laser irradiation further boosted their antimicrobial activity, and significantly accelerated the curing rate of wound. Comparing with Ag nanoplates, the irradiated porous Ag@Au nanoplates showed the similar antibiotic ability against S. aureus strains and lower cytotoxicity in Ann. When the porous Ag@Au nanoplates were applied to treat S. oureus-infected wound, they had the best curing effect. Thus, these porous Ag@Au nanoplates could act as promising antibacterial agents for wound healing applications.
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