期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 185, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2019.110601
关键词
Self-healing; Hydrogel; Poly(aspartic acid); Dynamic chemical bond; Bio-degradability
资金
- Natural Science Foundation of Hebei Province [B2017201019, B2018201140, H2019201084]
- Department of Education, Hebei Province [QN2017014]
- Hebei University [2017011, 2017014]
- Post-graduate's Innovation Fund Project of Hebei University [hbu2019ss010]
Self-healing hydrogels were prepared from hydrazide functionalized poly(aspartic acid) (PAsp). The polymer succinimide (PSI) was reacted with hydrazine and ethanolamine successively to obtain water soluble poly(aspartic acid) derivatives with hydrazide functional groups (PAEH). The hydrogel was prepared by cross-linking PAEH with poly(ethylene glycol) dialdehyde (PEG DA) under mild conditions without addition of catalyst. The rheological property and the self-healing property of the hydrogels were investigated intensively. The in vitro toxicity experiment showed the hydrogels have good bio-compatibility and the doxorubicin (DOX)-loaded hydrogels showed controlled release profile. Importantly, the hydrogel can still be degraded based on poly(aspartic acid) backbone. The bio-degradable poly(amino acid) based on self-healing hydrogel could have great potential application in bioscience including tissue repairing, drug loading and release.
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