期刊
CLINICAL NUCLEAR MEDICINE
卷 45, 期 2, 页码 133-135出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLU.0000000000002861
关键词
Tc-99m-mebrofenin; hepatectomy; hepatitis C; hepatobiliary scintigraphy
There is a growing interest in assessment of future remnant liver function with Tc-99m-mebrofenin hepatobiliary scintigraphy before major hepatectomy to estimate the risk of posthepatectomy liver failure. We illustrate the case of a 42-year-old woman with liver metastasis from colorectal cancer who performed hepatobiliary scintigraphy. Tc-99m-mebrofenin clearance rate of the total liver was considerably low. The patient recently started a treatment for active hepatitis C with a combination of 2 new direct-acting antiviral agents (grazoprevir, elbasvir). Apart from hypoalbuminemia or hyperbilirubinemia, physicians must be aware that drug interactions can interfere with Tc-99m-mebrofenin liver uptake, thereby resulting in a dramatic underestimation of liver function.
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