期刊
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
卷 75, 期 3, 页码 325-334出版社
IOS PRESS
DOI: 10.3233/CH-190786
关键词
Dynamic contrast enhanced ultrasound (D-CEUS); locally advanced pancreatic ductal adenocarcinoma (LAPC); chemoradiotherapy (CRT); therapeutic response; blood perfusion
资金
- National Natural Science Foundation of China [81571676, 81501471]
- Shanghai Municipal Science and Technology Medical Guidance Project [18411967200]
- Shanghai Municipal Science and Technology Innovation Action Plan Clinical Medicine Project [17411954200]
- Shanghai Municipal Health and Family Planning Commission Research Project [201840215]
- Chinese National key research and development program [2017YFC0112100]
OBJECTIVES: To investigate the value of dynamic contrast enhanced ultrasound (D-CEUS) in monitoring the chemoradiotherapy (CRT) therapeutic response of local advanced pancreatic ductal adenocarcinoma (LAPC). PATIENTS AND METHODS: From October 2017 to December 2018, 11 patients diagnosed as LAPC were included (7 men, 4 women; mean age: 61.1 +/- 8.6 years). The algorithm of CRT was as following: the radiotherapy dose was 50.4 Gy/28Fx with S-1 40 mg bid orally taken in radiotherapy day. Conventional ultrasound scan and CEUS were performed before and 4 weeks after CRT. All ultrasound examinations were performed by an ACUSON Oxana 2 ultrasound equipment (Siemens Medical Solutions, Germany) with a C 6-1 convex array transducer (1-6 MHz). Time intensity curves (TICs) were generated in the region of interests (ROIs) both in LAPC lesions and in its surrounding pancreas parenchyma by SonoLiver software (TOMTEC Imaging Systems). Quantitative perfusion parameters including maximum intensity (MI), rise time (RT), mean transit time (mTT) and time to peak (TTP) were analyzed and compared before and after CRT. RESULTS: No significant difference could be found by conventional B mode ultrasound scan after CRT. TICs of CEUS showed lower ascending and descending slopes rate after CRT. Among all perfusion quantitative parameters, MI decreased significantly after CRT (42.1 +/- 18.8% vs 27.8 +/- 17.2%, P < 0.05). CONCLUSIONS: Depending on its unique advantages as non-radiation, effective and convenient, D-CEUS analysis and quantitative parameters, particularly MI, has potential application value in following up of the CRT treatment response in LAPC patients.
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