期刊
CHINESE CHEMICAL LETTERS
卷 31, 期 7, 页码 1709-1716出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2020.02.007
关键词
Cancer therapy; Photodynamic therapy; Immunotherapy; Reactive oxygen species; Singlet oxygen
资金
- National Natural Science Foundation of China (NSFC) [81773667]
- NSFC Projects of International Cooperation and Exchanges [81811540416]
- China Pharmaceutical University [2242019K3DNZ2]
- Southeast University [2242019K3DNZ2]
- Nanjing Medical University [2242019K3DNZ2]
Photodynamic therapy (PDT) is a promising alternative approach for effective cancer treatment, which can directly destroy local tumor cells due to the generation of cytotoxic singlet oxygen and reactive oxygen species (ROS) in the tumor cells. Intriguingly, PDT-mediated cell death is also associated with anti-tumor immune response. However, immunosuppression of tumor microenvironment is able to limit the immune response induced by PDT, it is therefore necessary to combine with immunocheckpoint inhibitor and immunoadjuvant for synergistic treatment of tumors. Herein, the recent advances of PDT, immunotherapy, and photodynamic immunotherapy are reviewed (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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