期刊
CHINESE CHEMICAL LETTERS
卷 31, 期 7, 页码 1873-1876出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2020.01.042
关键词
Supramolecular chemistry; Calixarene; Self-assembly; Molecular recognition; Insulin fibrillation
资金
- National Natural Science Foundation of China [51873090, 21672112]
- Fundamental Research Funds for the Central Universities
Insulin fibrillation poses a variety of problems in biomedical and biotechnological applications of insulin. Inhibiting insulin fibrillation is highly on demand to address those problems. We herein demonstrate the capability of amphiphilic sulfonatocalixarene to inhibit insulin fibrillation. The amphiphilic assembly of p-sulfonatocalix[4]arene tetra dodecyl ether exhibits much better efficiency on inhibiting insulin fibrillation, with respect to p-sulfonatocalix[4]arene and sodium dodecyl benzenesulphonate. The pronounced inhibition effect results from both the preorganized scaffold of calixarene and the amphiphilic assembly. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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