期刊
CHEMOSPHERE
卷 243, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2019.125428
关键词
Drosophila melanogaster; Pb; Iron homeostasis; ROS; Ferritin
资金
- National Natural Science Foundation of China [31671284, 81773475]
- National Postdoctoral Program for Innovative Talents [BX201600045]
- Fundamental Research Funds for the Central Universities [PA2017GDQT0018]
- National Key Basic Research Program of China [2018YFC1602201, 2018YFC1602204]
- Key Laboratory of Xin'an Medicine Ministry of Education, Anhui University of Chinese Medicine [2018xayx01]
Toxic elements exposure disturbs the homeostasis of essential elements in organisms, but the mechanism remains elusive. In this study, we demonstrated that Drosophila melanogaster exposed to Lead (Pb, a pervasive environmental threat to human health) exhibited various health defects, including retarded development, decreased survival rate, impaired mobility and reduced egg production. These phenotypes could be significantly modulated by either intervention of dietary iron levels or altering expression of genes involved in iron metabolism. Further study revealed that Pb exposure leads to systemic iron deficiency. Strikingly, reactive oxygen species (ROS) clearance significantly increased iron uptake by restoring the expression of iron metabolism genes in the midgut and subsequently attenuated Pb toxicity. This study highlights the role of ROS in Pb induced iron dyshomeostasis and provides unique insights into understanding the mechanism of Pb toxicity and suggests ideal ways to attenuate Pb toxicity by iron supplementation therapy or ROS clearance. (C) 2019 Elsevier Ltd. All rights reserved.
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