期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 15, 期 1, 页码 156-162出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201901490
关键词
Homobenzylic Fluoride; Methodology and Reactions; Nickel; Reductive Coupling; Unactivated bond
资金
- National Natural Science Foundation of China [21502131]
- Science & Technology Department of Sichuan Province [2018JZ0061, 2018HH0128]
- Education Department of Sichuan Province [18CZ0024]
- Key Laboratory of Vanadium and Titanium of Sichuan Province [2018FTSZ03]
- Sichuan University of Science and Engineering [2017RCL03]
We report herein a facile synthetic method for converting unactivated (hetero)aryl electrophiles into beta-fluoroethylated (hetero)arenes via nickel-catalyzed reductive cross-couplings. This coupling reaction features the involvement of FCH2CH2 radical intermediate rather than beta-fluoroethyl manganese species which provides effective solutions to the problematic beta-fluoride side eliminations. The practical value of this protocol is further demonstrated by the late-stage modification of several complex ArCl or ArOH-derived bioactive molecules.
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