期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 15, 期 3, 页码 415-424出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201901523
关键词
Aziridine synthon; Chiral auxiliary; Collective synthesis; Pipecolic acid; Tamiflu
资金
- UGC, New Delhi
- CSIR, New Delhi [CSC-0108, CSC-0301]
A unified synthetic strategy for oseltamivir phosphate (tamiflu), (S)-pipecolic acid, and its 3-hydroxy derivatives from furan derived common chiral bicycloaziridino lactone synthon is described here. Key features are the short (4-steps), enantiopure, and decagram-scale synthesis of common chiral synthon from furan and its first-ever application in the total synthesis of biologically active compounds by taking the advantages of high functionalization ability of chiral synthon.
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