4.6 Article

Simultaneous Production of Psilocybin and a Cocktail of β-Carboline Monoamine Oxidase Inhibitors in Magic Mushrooms

期刊

CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 3, 页码 729-734

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201904363

关键词

alkaloids; ayahuasca; beta-carboline; natural products; psilocybin

资金

  1. Deutsche Forschungsgemeinschaft (DFG) [HO2515/7-1]
  2. DFG Collaborative Research Center CRC 1127 (ChemBioSys)

向作者/读者索取更多资源

The psychotropic effects of Psilocybe magic mushrooms are caused by the l-tryptophan-derived alkaloid psilocybin. Despite their significance, the secondary metabolome of these fungi is poorly understood in general. Our analysis of four Psilocybe species identified harmane, harmine, and a range of other l-tryptophan-derived beta-carbolines as their natural products, which was confirmed by 1D and 2D NMR spectroscopy. Stable-isotope labeling with C-13(11)-l-tryptophan verified the beta-carbolines as biosynthetic products of these fungi. In addition, MALDI-MS imaging showed that beta-carbolines accumulate toward the hyphal apices. As potent inhibitors of monoamine oxidases, beta-carbolines are neuroactive compounds and interfere with psilocybin degradation. Therefore, our findings represent an unprecedented scenario of natural product pathways that diverge from the same building block and produce dissimilar compounds, yet contribute directly or indirectly to the same pharmacological effects.

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