期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 11, 页码 2456-2463出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201905075
关键词
drug delivery; molecular recognition; nanostructures; self-assembly; supramolecular chemistry
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, Argentina) [PIP 0370]
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT, Argentina) [PICT-2016-1680, PICT-2017-1523]
- Austrian Institute of Technology GmbH (AIT-CONICET Partner Group: Exploratory Research for Advanced Technologies in Supramolecular Materials Science) [Exp. 4947/11, 3911]
- Universidad Nacional de La Plata (UNLP)
- CONICET
Polyamine-salt aggregates (PSA) are biomimetic soft materials that have attracted great attention due to their straightforward fabrication methods, high drug-loading efficiencies, and attractive properties for pH-triggered release. Herein, a simple and fast multicomponent self-assembly process was used to construct cross-linked poly(allylamine hydrochloride)/phosphate PSAs (hydrodynamic diameter of 360 nm) containing glucose oxidase enzyme, as a glucose-responsive element, and human recombinant insulin, as a therapeutic agent for the treatment of diabetes mellitus (GI-PSA). The addition of increasing glucose concentrations promotes the release of insulin due to the disassembly of the GI-PSAs triggered by the catalytic in situ formation of gluconic acid. Under normoglycemia, the GI-PSA integrity remained intact for at least 24 h, whereas hyperglycemic conditions resulted in 100 % cargo release after 4 h of glucose addition. This entirely supramolecular strategy presents great potential for the construction of smart glucose-responsive delivery nanocarriers.
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