期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 27, 页码 6064-6069出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202000515
关键词
carbon dioxide; carboxylation; C-H activation; green solvent; late-stage functionalization
资金
- NordForsk [85378]
- Tromso Research Foundation [TFS2016KHH]
A formal C-H carboxylation of unactivated arenes using CO2 in green solvents is described. The present strategy combines a sterically controlled Ir-catalyzed C-H borylation followed by a Cu-catalyzed carboxylation of the in situ generated organoboronates. The reaction is highly regioselective for the C-H carboxylation of 1,3-disubstituted and 1,2,3-trisubstituted benzenes, 1,2- or 1,4-symmetrically substituted benzenes, fluorinated benzenes and different heterocycles. The developed methodology was applied to the late-stage C-H carboxylation of commercial drugs and ligands.
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