期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 9, 页码 1906-1921出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201903961
关键词
allylic compounds; cyclization; nucleophilic substitution; synthetic methods; total synthesis
资金
- Tamaki Foundation
- Chugai Pharmaceuticals
Metal-catalyzed allylic alkylation reactions between dual nucleophiles and dual electrophiles represent a powerful set of methods for the synthesis of small-, medium-, and even large-sized rings. Using this strategy, a handful of simple allylic diol derivatives can be transformed into a broad array of complex carbo- and heterocycles of varying ring sizes in just a single step. Because of their ability to rapidly generate complexity, annulative allylic alkylation reactions between dual nucleophiles and dual electrophiles have been extensively employed in the total synthesis of both natural products and pharmaceutical compounds.
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