期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 3, 页码 629-633出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201905078
关键词
alkenes; asymmetric catalysis; gold; homogeneous catalysis; ligand design
资金
- Spanish MINECO [CTQ2016-76908-C2-1-P, CTQ2016-76908-C2-2-P]
- European FEDER funds
- Junta de Andalucia [2012/FQM1078]
The formal insertion of alkenes into aromatic chloro- and bromoalkynes takes place under cationic gold catalysis. This haloalkynylation reaction can be performed with cyclic, gem-disubstituted and monosubstituted alkenes, using BINAP, triazolo[4,3-b]isoquinolin-3-ylidene ligands or SPhos, respectively. The products were isolated in moderate to excellent yields and with complete diastereo- and regioselectivity; the halogen atom bonding the more substituted carbon of the alkene. Preliminary experiments showed that the enantioselective haloalkynylation of cyclopentene can be performed with (S)-BINAP to afford the insertion products with moderate to good enantioselectivities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据