期刊
CHEMISTRY OF MATERIALS
卷 32, 期 5, 页码 2180-2193出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.0c00290
关键词
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资金
- National Natural Science Foundation of China [81801848, 81961160736]
- Sichuan Science and Technology Program [2017FZ0046, 2018JZ0026]
- Young Elite Scientist Sponsorship Program, CAST, Chengdu International Science and Technology Cooperation Foundation [2017-GH02-00025-HZ]
- State Key Laboratory of Polymer Materials Engineering [sklpme2019-2-05]
- Sichuan University Postdoctoral Interdisciplinary Innovation Foundation
- Doctoral Fund of the Affiliated Hospital of Southwest Medical University [18059]
- Sichuan Province-Luzhou City-Southwest Medical Foundation [14JC0038]
- Scientific Projects of Sichuan Education Department [18ZA05193D]
- Australian Research Council
- USQ Strategic Research Fund
Biomaterial-associated infection (BAI) is a serious threat to patients' health. In general, bacteriostatic agents are loaded on the surface of biomaterials to eliminate BAI; however, the excessive usage of these agents leads to the emergence of drug-resistant bacteria and inadequacy of tissue repair. To address this issue, here, we create a photoresponsive and osteopromotive coating that consists of graphene oxide (GO) nanosheets, polydopamine (pDA) nanolayers, and adiponectin (APN) protein on bioinert sulfonated poly(etheretherketone) (sPEEK/GO/APN). The functionalized samples display superior cytocompatibility and in vitro osteogenicity regarding cell reproduction, spreading, alkaline phosphatase activity, extracellular matrix calcification, and osteo-associated genes expression, outperforming sPEEK/GO and sPEEK/APN samples. The in vivo evaluation using a rabbit femur defect model demonstrates that the multifunctional coating significantly boosts bone regeneration and osseointegration. More importantly, the GO/pDA complex bonded together through pi-pi stacking and electrostatic interactions gives rise to robust cyclic photothermal bacteria-killing ability toward both Gram-positive and Gram-negative bacteria. Such a surface engineering platform may enable biomedical implants with enhanced osteogenetic ability and remotely recyclable photodisinfection, holding great potential in the treatment of incurable infective bone loss.
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