期刊
CHEMICAL ENGINEERING JOURNAL
卷 382, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2019.122720
关键词
Bismuth nanoparticles; Degradation; pH/NIR-responsive drug release; Cancer imaging and therapy
资金
- National Natural Science Foundation of China [21573040, 21603029]
- Natural Science Foundation and Science and Technology Development Planning of Jilin Province [20150204086GX, 20170520148JH]
- Jilin Provincial Research Foundation for Basic Research [20160519012JH]
- Jilin Provincial Key Laboratory of Micro-Nano Functional Materials (Northeast Normal University)
- China Postdoctoral Science Foundation [2016M600224]
To avoid toxicity of multifunctional nanomaterials in bioapplication, the biodegradable inorganic nanoparticles (NPs) must be our main focus. In the work, we firstly developed green biomolecules-mediated bismuth (Bi) NPs based on single-step reduction reaction in aqueous phase, which could be degraded in the tumor microenvironment. Various biomolecules including gelatin (GEL), bovine serum albumin (BSA) or human serum albumin (HAS) were investigated to fabricate Bi@GEL, Bi@BSA or Bi@HSA NPs (BGPs, BBPs or BHPs). Moreover, the experimental explorations further confirmed that the BGPs owned multiple optimal features such as X-ray computed tomography (CT) and infrared thermal (IRT) imaging capacities, drug loading and pH/NIR-responsive drug release abilities as well as antitumor effects of synergistic chemo-photothermal therapy (CPTT). Our work provides a new pH-responsive biodegradable inorganic nanomaterial for versatile cancer theranostics.
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