期刊
BONE
卷 89, 期 -, 页码 25-31出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2016.05.003
关键词
Antidepressants; Bone loss; Bone mineral density; Osteoporosis; Postmenopausal women; Selective serotonin reuptake inhibitors
资金
- University of Eastern Finland
- Academy of Finland [115969, 250707]
- Ministry of Education and Culture
- Kuopio University Hospital (VTR)
- Finnish Concordia Fund
- National Doctoral Programme of Musculoskeletal Disorders and Biomaterials
- North Savo Regional Fund of Finnish Cultural Foundation [GNT 65142185]
- Saastamoinen Foundation
- EVO grant from Lapland Hospital District
- Eli Lilly
- Pfizer
- University of Melbourne
- Deakin University
- National Health and Medical Research Council (NHMRC)
- NHMRC Career Development Fellowship [GNT 1064272]
- Academy of Finland (AKA) [250707, 115969, 115969, 250707] Funding Source: Academy of Finland (AKA)
Background: Osteoporosis and depression are major health problems worldwide. The association between antidepressants, a treatment for depression, and bone health needs more detailed exploration. Objective: The present study investigates antidepressant medication use and postmenopausal bone loss over time. Methods: A total of 1988 women (aged 57-67) participating in the Kuopio Osteoporosis Risk Factor and Prevention Study (OSTPRE) cohort responded to a postal enquiry and had their femoral neck bone mineral density (BMD) measured in 1999 and again in 2004. Data on antidepressant use was obtained from the National Prescription Register. Multiple regression techniques were used to test the associations, before and after adjustment for anthropometric, medical, physical and lifestyle factors. Results: Over the five years of follow-up, 319 (16.0%) women purchased antidepressants. Mean baseline femoral neck BMD for the entire study group was 881 mg/cm(2) (SD 123) and mean 5-year bone loss was 6.0 mg/cm2 (SD 4.7). After adjustments, users of tricyclic antidepressants (TCA) had greater annual BMD loss than non-users ( 3.6 mg/cm(2) vs. 1.1 mg/cm(2); P = 0.031). Accelerated bone loss was also associated with selective serotonin reuptake inhibitor's (SSRI) use (P = 0.001) and use of other antidepressants in a dose-response way, with the latter only among women of low-weight and normal-weight women who had lost weight over the study period. Conclusions: In conclusion, the use of SSRIs seems to accelerate postmenopausal bone loss in a dose-response manner. Associations between TCA and other antidepressant use and bone loss may also exist. Thus, the possibility of increased risk of osteoporosis should be considered when prescribing antidepressants for postmenopausal women. (C) 2016 Elsevier Inc All rights reserved.
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