期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 68, 期 1, 页码 46-57出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c19-00911
关键词
1,4-naphthoquinone; chemical structure; biological property; molecular target
资金
- Russian Science Foundation [19-14-00047]
- Russian Science Foundation [19-14-00047] Funding Source: Russian Science Foundation
Over the past decade, a number of new 1,4-naphthoquinones have been isolated from natural sources and new 1,4-naphthoquinones with diverse structural features have been synthesized. Cardioprotective, anti-ischemic, hepatoprotective, neuroprotective and some other new properties were found for these compounds; their role in protecting against neurodegenerative diseases has been established. Their anti-inflammatory, antimicrobial and antitumor activities have been studied in more detail; new, previously unknown intracellular molecular targets and mechanisms of action have been discovered. Some compounds of this class are already being used as a medicinal drugs and some substances can be used as biochemical tools and probes for non-invasive detection of pathological areas in cells and tissues in myocardial infarction and neurodegenerative diseases using modern molecular imaging techniques.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据