期刊
CHEMCATCHEM
卷 12, 期 10, 页码 2849-2858出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.202000292
关键词
dynamic kinetic resolution; heterogeneous catalysis; lipase; sec-alcohols; vanadium
资金
- FAPESP [2014/50249-8]
- GlaxoSmithKline
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
Herein, we present a robust and eco-friendly dynamic kinetic resolution (DKR) protocol for secondary alcohols using a combined heterogeneous catalytic CAL-B/VOSO4 system at 50 degrees C in the relatively green solvent heptane. This catalytic system is active and chemo- and enantioselective for up to 5 cycles. A set of 13 aromatic and heteroaromatic secondary alcohols were evaluated to determine the substrate scope. The performance of the combined CAL-B/VOSO4 system was improved by employing a low-cost, homemade Teflon tube to compartmentalize the catalysts in one-pot conditions, making this system for up to 8 reaction cycles.
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