期刊
CEREBRAL CORTEX
卷 30, 期 6, 页码 3731-3743出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhz338
关键词
dentate gyrus; hippocampus; immediate early gene; plasticity; Sox11
资金
- German Research Foundation [LI 858/9-1, INST 410/45-1 FUGG]
- Bavarian Research Network ForIPS
- University Hospital Erlangen (IZKF) [E12, E21, E16]
- Deutsche Forschungsgemeinschaft [270949263/DFG GRK2162/1]
- Bavarian Research Network ForINTER
Neuronal activity initiates transcriptional programs that shape long-term changes in plasticity. Although neuron subtypes differ in their plasticity response, most activity-dependent transcription factors (TFs) are broadly expressed across neuron subtypes and brain regions. Thus, how region- and neuronal subtype-specific plasticity are established on the transcriptional level remains poorly understood. We report that in young adult (i.e., 6-8 weeks old) mice, the developmental TF SOX11 is induced in neurons within 6 h either by electroconvulsive stimulation or by exploration of a novel environment. Co Strikingly, SOX11 induction was restricted to the dentate gyrus (DG) of the hippocampus. In the novel environment paradigm, SOX11 was observed in a subset of c-FOS expressing neurons (ca. 15%); whereas around 75% of SOX11+ DG granule neurons were c-FOS+, indicating that SOX11 was induced in an activity-dependent fashion in a subset of neurons. Environmental enrichment or virus-mediated overexpression of SOX11 enhanced the excitability of DG granule cells and downregulated the expression of different potassium channel subunits, whereas conditional Sox11/4 knock-out mice presented the opposite phenotype. We propose that Sox11 is regulated in an activity-dependent fashion, which is specific to the DG, and speculate that activity-dependent Sox11 expression may participate in the modulation of DG neuron plasticity.
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