期刊
CEREBRAL CORTEX
卷 30, 期 6, 页码 3820-3826出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhz344
关键词
axons; corpus callosum; cortical connections; development; transient projections
In addition to neuronal death and elimination of synapses, the production of transient, exuberant axons, and axonal branches is a general phenomenon in development across species and systems. To understand what drives the decision of which axons are maintained and which are eliminated, it is important to monitor the interaction of juvenile axons at their target. As old and more recent work show, unlike what is claimed by Ribeiro Gomez et al. (2019), in the cerebral cortex, both classes of axons branch in the white matter near the target; axons destined to be maintained massively invade the gray matter where they develop terminal arbors and synapses. Axons destined to elimination remain in the white matter although a few transient, exploratory branches can enter the cortex. Axonal behavior and fate seem dictated by positional information probably conveyed by thalamic afferents and activity. Unlike what is suggested by Ribeiro Gomez et al. (2019), axonal selection should not be confused with synaptic reduction, which is a later event with minor or no impact on the topography of the connection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据