期刊
CEREBRAL CORTEX
卷 30, 期 5, 页码 2777-2788出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhz274
关键词
CAH; cortical thickness; subcortical volume; white matter integrity; working memory
资金
- Marianne and Marcus Wallenberg Foundation
- International Fund raising for Congenital Adrenal Hyperplasia (IFCAH)/European Society for Pediatric Endocrinology (ESPE)
- Stockholm County Council (ALF-SLL)
- Foundation of Lisa and Johan Gronberg
- Stiftelsen Frimurare Barnhuset i Stockholm
- Samaritan Foundation
- Jerringfonden Foundation
- Sallskapet Barnavard Foundation
- Wera Ekstroms stiftelse for Pediatrik Forskning
- Foundation for Research and Education in Pediatric Endocrinology
Congenital adrenal hyperplasia (CAH) has been associated with brain structure alterations, but systematic studies are lacking. We explore brain morphology in 37 (21 female) CAH patients and 43 (26 female) healthy controls, aged 16-33 years, using structural magnetic resonance imaging to estimate cortical thickness, surface area, volume, subcortical volumes, and white matter (WM) microstructure. We also report data on a small cohort of patients (n = 8) with CAH, who received prenatal dexamethasone (DEX). Patients with CAH had reduced whole brain volume (4.23%) and altered structure of the prefrontal, parietal, and superior occipital cortex. Patients had reduced mean FA, and reduced RD and MD, but not after correcting for brain volume. The observed regions are hubs of the visuospatial working memory and default mode (DMN) networks. Thickness of the left superior parietal and middle frontal gyri was associated with visuospatial working memory performance, and patients with CAH performed worse on this task. Prenatal treatment with DEX affected brain structures in the parietal and occipital cortex, but studies in larger cohorts are needed. In conclusion, our study suggests that CAH is associated with brain structure alterations, especially in the working memory network, which might underlie the cognitive outcome observed in patients.
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