期刊
CELLULAR MICROBIOLOGY
卷 22, 期 3, 页码 -出版社
WILEY
DOI: 10.1111/cmi.13152
关键词
Danio rerio; gastrointestinal tract; host-pathogen interactions; infection model; microbiome; microbiota; zebrafish
资金
- NIAID NIH HHS [R21 AI151259, T32 AI055449, R01 AI132354] Funding Source: Medline
- NIGMS NIH HHS [R01 GM124043] Funding Source: Medline
The zebrafish (Danio rerio) has become a widely used vertebrate model for bacterial, fungal, viral, and protozoan infections. Due to its genetic tractability, large clutch sizes, ease of manipulation, and optical transparency during early life stages, it is a particularly useful model to address questions about the cellular microbiology of host-microbe interactions. Although its use as a model for systemic infections, as well as infections localised to the hindbrain and swimbladder having been thoroughly reviewed, studies focusing on host-microbe interactions in the zebrafish gastrointestinal tract have been neglected. Here, we summarise recent findings regarding the developmental and immune biology of the gastrointestinal tract, drawing parallels to mammalian systems. We discuss the use of adult and larval zebrafish as models for gastrointestinal infections, and more generally, for studies of host-microbe interactions in the gut.
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