期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 77, 期 16, 页码 3077-3083出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03444-3
关键词
Hypoxia-inducible factors; Tumor malignant behavior; Chemoresistant
Pancreatic cancer (PC) remains one of the most extremely lethal malignancies worldwide due to late diagnosis and early metastasis, with a 1-year overall survival rate of approximately 20%. The hypoxic microenvironment, induced by intratumoral hypoxia, promotes tumor invasion and progression, leading to chemotherapy or radiotherapy resistance and eventual mortality after treatment of PC. However, the role of the hypoxic microenvironment in PC is complicated and requires further investigation. In this article, we review recent advances regarding the regulation of malignant behaviors in PC, which provide insight into the potential of hypoxic microenvironment activation therapy for the therapeutic agents.
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