期刊
CELLULAR & MOLECULAR BIOLOGY LETTERS
卷 25, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s11658-020-0199-0
关键词
DNA-PK; Shelterin; Telomerase; Telomere; hnRNP-A1
资金
- National Natural Science Foundation of China [81802740]
- Natural Science Foundation of Chongqing City [cstc2018jcyjAX0741]
- Cancer Prevention Research Institute of Texas [RP160268]
- National Institutes of Health [CA233594]
This review focuses on DNA-dependent protein kinase (DNA-PK), which is the key regulator of canonical non-homologous end-joining (NHEJ), the predominant mechanism of DNA double-strand break (DSB) repair in mammals. DNA-PK consists of the DNA-binding Ku70/80 heterodimer and the catalytic subunit DNA-PKcs. They assemble at DNA ends, forming the active DNA-PK complex, which initiates NHEJ-mediated DSB repair. Paradoxically, both Ku and DNA-PKcs are associated with telomeres, and they play crucial roles in protecting the telomere against fusions. Herein, we discuss possible mechanisms and contributions of Ku and DNA-PKcs in telomere regulation.
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