期刊
CELL STEM CELL
卷 26, 期 3, 页码 441-+出版社
CELL PRESS
DOI: 10.1016/j.stem.2020.01.012
关键词
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资金
- Swedish Research Council
- Swedish Cancer Society
- Swedish Foundation for Strategic Research
- Center for Innovative Medicine
- Ragnar Soderberg Foundation
- LEO Foundation
- Goran Gustafsson Foundation
- Karolinska Institutet PhD (KID)
- Wenner-Gren postdoctoral fellowship
Skin homeostasis is orchestrated by dozens of cell types that together direct stem cell renewal, lineage commitment, and differentiation. Here, we use single-cell RNA sequencing and single-molecule RNA FISH to provide a systematic molecular atlas of full-thickness skin, determining gene expression profiles and spatial locations that define 56 cell types and states during hair growth and rest. These findings reveal how the outer root sheath (ORS) and inner hair follicle layers coordinate hair production. We found that the ORS is composed of two intermingling but transcriptionally distinct cell types with differing capacities for interactions with stromal cell types. Inner layer cells branch from transcriptionally uncommitted progenitors, and each lineage differentiation passes through an intermediate state. We also provide an online tool to explore this comprehensive skin cell atlas, including epithelial and stromal cells such as fibroblasts, vascular, and immune cells, to spur further discoveries in skin biology.
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