期刊
CELL METABOLISM
卷 31, 期 3, 页码 445-447出版社
CELL PRESS
DOI: 10.1016/j.cmet.2020.02.006
关键词
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资金
- Netherlands Heart Foundation (IN CONTROL) [CVON2018-27]
- Noaber Foundation, Lunteren, the Netherlands
- Nutrition & Health initiative of the University of Groningen
- European Genomic Institute for Diabetes (EGID) [ANR-10-LABX-46]
- European Commission
- Agence Nationale pour la Recherche (ANR-FXREn)
- European Research Council [694717]
The microbiome is well known to influence the immune response of the host. Song et al. now show that the microbiome modulates adaptive immunity in mice through formation of bile acid species acting on ROR gamma(+) regulatory T cells via the Vitamin D Receptor, thereby lowering the vulnerability for chemically induced colitis.
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