4.8 Editorial Material

The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved!

期刊

CELL METABOLISM
卷 31, 期 1, 页码 13-15

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CELL PRESS
DOI: 10.1016/j.cmet.2019.12.007

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资金

  1. European Research Council (ERC) [647057]
  2. Associazione Italiana Ricerca sul Cancro (AIRC) [20119]
  3. European Research Council (ERC) [647057] Funding Source: European Research Council (ERC)

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Although confirmed as the primary lipophilic antioxidant molecule endogenously produced by cells, the non-mitochondrial pool of CoQ10's functional role is still well debated. Recently, both Bersuker et al. (2019) and Doll et al. (2019) have identified FSP1 as a novel CoQ10 plasma membrane oxidoreductase, protecting cells from glutathione-independent ferroptosis.

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