期刊
CELL CALCIUM
卷 86, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2020.102159
关键词
Sodium (Na+) pump; Na+, K+-ATPase (NKA); Sodium/calcium exchange (NCX); Calcium signaling; Cardiotonic steroids (CTS); Ouabain; Endogenous ouabain (EO); Kidneys; Heart; Brain; Protein kinase (PK) cascade; Src kinase; Reactive oxygen species (ROS); Immune response
类别
资金
- National Heart Lung and Blood Institute, National Institutes of Health [HL-45215, HL-78870, HL-107555, HL-75584]
- American Heart Association [15GRNT24940022]
- Alexander von Humboldt Foundation Senior Scientist Award
- University of Maryland School of Medicine
- University of Maryland Baltimore Foundation
In this brief review we discuss some aspects of the Na+ pump and its roles in mediating the effects of ouabain and endogenous ouabain (EO): i) in regulating the cytosolic Ca2+ concentration ([Ca2+]CYT) via Na/Ca exchange (NCX), and ii) in activating a number of protein kinase (PK) signaling cascades that control a myriad of cell functions. Importantly, [Ca2+] CYT and the other signaling pathways intersect at numerous points because of the influence of Ca2+ and calmodulin in modulating some steps in those other pathways. While both mechanisms operate in virtually all cells and tissues, this article focuses primarily on their functions in the cardiovascular system, the central nervous system (CNS) and the kidneys.
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