Crystalline loading of lipophilic Coenzyme Q10 pharmaceuticals within conjugated carbon aerogel derivatives

Low-density aerogel materials are a promising platform for delivering lipophilic drugs with poor water solubility, but to date, the loading of aerogels with pharmaceuticals in crystalline form has not been reported other than by expensive supercritical loading techniques. Here, we demonstrate a simple and low-cost liquid-phase impregnation method to load the model drug coenzyme Q(10) (CoQ(10)) within carbon aerogels. By controlling the chemical microstructure of the aerogel to exhibit pi-conjugated (sp(2)) bonding via addition of graphene oxide, the rate of adsorption and total loading of CoQ(10) is significantly enhanced. Furthermore, the adsorbed CoQ(10) adopts an as-yet unreported crystalline phase that differs from the bulk material, not only offering the potential advantages of crystalline materials for drug delivery, but also a means to control the microstructure of this important lipophilic pharmaceutical. (C) 2020 Elsevier Ltd. All rights reserved.