期刊
CARBOHYDRATE RESEARCH
卷 488, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2019.107891
关键词
Adsorption; Ibuprofen; Antibacterial; Multifunctional materials; Drug delivery
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) in Brazil
- Brazilian bureau Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Federal University of Tocantins
The wide use of chitosan microspheres in pharmaceutical applications, mainly in the controlled release of drugs and as a bactericidal agent, has been widely reported in the literature. However, these important biomaterial applications with multifunctionality is still scarce. In this study, epichlorohydrin-crosslinked chitosan microspheres were prepared and evaluated for Ag+ adsorption and formation of silver nanoparticles. The hybrid material obtained was used to antibacterial activity and controlled drug release. The optimal pH for adsorption of Ag+ ions in aqueous medium was pH 5-7; the best fit was the Langmuir model; the optimal time for maximum adsorption was 10 h. The highest release of the drug occured at neutral pH of the intestinal fluids and remained constant for 6 h. Silver ion microspheres demonstrated activity against E. coli and S. aureus. The concentration of ibuprofen incorporated in the chitosan microspheres was 7.9 x 10(-3) mol L-1 and in the microspheres with AgNPs the concentration was 1.8 x 10(-2) mol L-1. The microspheres with AgNPs released more drug (77%) than the material without AgNPs.
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