期刊
CARBOHYDRATE POLYMERS
卷 229, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115436
关键词
Polysaccharide; Chemical modification; Anti-tumor activity; Mechanism
资金
- National Natural Science Foundation of China [81960708]
- Natural Science Foundation of Jiangxi province, China [20171BCB23022]
- National Youth Top-notch Talent Support Program of China
With the rising trend of incidence of cancers, effective therapies are urgently needed to control human malignancies. However, the chemotherapy drugs currently on the market cause serious side effects. Polysaccharides belong to a class of biomacromolecules, which have drawn considerable research interest over the years as it possess anti-cancer activities or can increase the efficacy of conventional chemotherapy drugs with fewer side effects. The antitumor activity of many polysaccharides was significantly increased after modification. Based on these encouraging observations, a great deal of effort has been focused on discovering anti-cancer polysaccharides and modified derivatives for the development of effective therapeutics for various human cancers. This review highlights recent advances on the major chemical modification methods of polysaccharides, and discusses the effect of molecular modification on the physicochemical properties and anti-tumor activities of polysaccharides. Meanwhile, the underlying anti-tumor mechanisms of polysaccharide and its modified derivatives were also discussed.
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