期刊
CARBOHYDRATE POLYMERS
卷 229, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115432
关键词
Floccularia luteovirens; Exopolysaccharides; Antioxidant activity; Structural characterization; Anticancer activity
资金
- National Nature Science Foundation of China [31960471, 31871904]
- Nature Science Foundation of Zhejiang Province [LR13C200002]
Two polysaccharides, ALF1 and ALF2 were obtained from the fermentation liquid of Floccularia luteovirens. These fractions had good performance in scavenging radicals and ALF1 exhibited obvious antioxidant activities. Further, linkage analysis and NMR were used to characterize the structures of ALF1. Linkage and NMR data comprehensively showed that ALF1 mainly contained six kinds of linkage type units as -> 4)-beta-D-Manp ->, 1,3-alpha-Fucp ->, alpha-L-Araf-C1 ->, -> 6)-beta-D-Galp-C1 ->,-> 4)-alpha-D-GlcAp-(1 -> and -> 3)-beta-D-Glcp(1 ->. In addition, ALF1 had good bioactivities such as anticancer and antioxidant activities. ALF1 was proven to be able to inhibit tumor cells without affecting the normal cells. Besides, ALF1 improved the activities of SOD, GSH-Px and CAT, and decreased the production of MDA which result in protecting PC12 cells against H2O2-induced oxidative stress. ALF1 decreased ROS production, and stabilize mitochondrial membrane potential. The findings indicated that the fermentation liquid of Floccularia luteovirens could be used as a potential natural source of antioxidant.
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