期刊
CARBOHYDRATE POLYMERS
卷 231, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115734
关键词
Chitosan; Waterborne polyurethane; Wound healing; Stem cell therapy
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [CAPES/PDSE-BEX: 1408/11-9]
- Spanish Ministry of Economy and Competitiveness (MINECO) [MAT2016-76039-C4-1-R]
- FEDER
- VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions
- Instituto de Salud Carlos III
- European Regional Development Fund
Foot ulcers, a common complication of diabetes, can cause physical incapacity and are derived from several factors, including poor wound healing. New therapeutic strategies are needed to minimize this complication for the sake of patients' health. We therefore developed a new chitosan- polyurethane hydrogel membrane (HPUC) and the WA results confirmed that HPUC present low cytotoxicity and improved wound healing when used with mononuclear bone marrow fraction cells in the diabetic rat model. The biodegradable hydrogels were produced in block copolymer networks with a combination of chitosan blocks and biodegradable polyurethane. The membranes were characterized by FTIR, C-13-NMR and thermogravimetry. Swelling and hydrolytic degradation were also evaluated. The non-solubility of the membranes in good solvents and the chemical characterization confirmed that the network structure was formed between the PU and the chitosan through urea/urethane bonds. The findings confirm that the HPUC have interesting properties that make them suitable for wound healing applications.
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