期刊
CARBOHYDRATE POLYMERS
卷 229, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115523
关键词
Dual physically cross-linked; Mechanical properties; Tribological properties; Biocompatibility; Cartilage repair
资金
- National Natural Science Foundation of China [51173070]
- National Natural Science Foundation of Guangdong, China [2016A030313097]
- Science and Technology Program of Guangzhou, China [201707010264]
Hydrogels with desirable characteristics have been supposed to be potential materials for cartilage repair. However, the biomechanical, biotribological and biocompatible properties of hydrogels remain some crucial challenges. To address these challenges, we developed a dual physically cross-linked poly (vinyl alcohol)-(nano hydroxyapatite)/(2-hydroxypropyltrimethyl ammonium chloride chitosan) (PVA-HA/HACC-Cit) hydrogels with double-network (DN) through a simply freezing/thawing technique and an immersing process. The DN hydrogel with an optimized HA concentration exhibited outstanding fracture tensile stress (2.70 +/- 0.24 MPa), toughness (14.09 +/- 2.06 MJ/m(3)) and compressive modulus (0.88 +/- 0.09 MPa). In addition, the PVA-HA/HACC-Cit DN hydrogels demonstrated remarkable anti-fatigue property, extraordinary self-recovery and energy dissipation ability due to their unique dual physically cross-linked structures. Moreover, the low friction coefficient, the predominant wear resistance property, as well as the excellent cytocompatibility were realized for the DN hydrogels because of the existence of nano-hydroxyapatite. Thus, this work puts forward a new strategy in the preparation of DN hydrogels for promising applications in cartilage repair.
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