期刊
CARBOHYDRATE POLYMERS
卷 229, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115478
关键词
Drug delivery system; Drug carrier; Aggregate; beta-CD; PEG; Guanosine; Dox; beta-CD-PEG-G; beta-CD-PEG-G-Dox; Nanomedicine
资金
- NSFC [21201020]
- Shandong Provincial Independent Innovation and Achievements Transformation Foundation [2014CGZH1316]
- Projects of Shandong Province Higher Educational Science and Technology Program [J16LC19, J15LC01]
- Key Research and Development Plan of Yantai [2016ZH078, 2018XSCC050]
- foundation of Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, China [201703]
The clinical use of many chemotherapeutic drugs is considerably greatly limited due to their serious side effects. This problem can be solved by using a low-toxic or nontoxic drug carrier that exhibits excellent performance in entrapping chemotherapeutic drugs. Accordingly, beta-cyclodextrin-PEG-guanosine (beta-CD-PEG-G) molecule was first synthesized. The molecules can self-assemble into negatively charged spherical aggregates (called beta-CD-PEG-G aggregates) that can stably exist in an aqueous solution and entrap doxorubicin (Dox) to form beta-CD-PEG-G-Dox nanomedicine. Dox encapsulation efficiency is approximately 79 +/- 6.3%. Dox from beta-CD-PEG-G-Dox nanomedicine exhibits sustained release and pH responsiveness. Cell and animal experiments showed that beta-CD-PEG-G-Dox nanomedicine could effectively induce cancer cell apoptosis to exert antitumor activity. Unexpectively, the animal experiment and tissue sections demonstrated that beta-CD-PEG-G aggregates exhibit certain antitumor activity that could delay the tumor growth. Therefore, the beta-CD-PEG-G molecule has high potential as a drug carrier candidate.
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