期刊
CANCER LETTERS
卷 470, 期 -, 页码 75-83出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2019.08.014
关键词
Lung cancer; Lipidomics; Phenomics; Biomarkers; Trans-omics
类别
资金
- Zhongshan Distinguished Professor Grant
- National Nature Science Foundation of China [91230204, 81270099, 81320108001, 81270131, 81300010, 81700008, 81873409]
- Shanghai Committee of Science and Technology [12JC1402200, 12431900207, 11410708600, 14431905100]
- Operation funding of Shanghai Institute of Clinical Bioinformatics, Ministry of Education for Academic Special Science and Research Foundation for PhD Education [20130071110043]
- National Key Research and Development Program [2016YFC0902400, 2017YFSF090207]
Disordered lipid metabolisms have been evidenced in lung cancer as well as its subtypes. Lipidomics with indepth mining is considered as a critical member of the multiple omics family and a lipid-specific tool to understand disease-associated lipid metabolism and disease-specific dysfunctions of lipid species, discover biomarkers and targets for monitoring therapeutic strategies, and provide insights into lipid profiling and pathophysiological mechanisms in lung cancer. The present review describes the characters and patterns of lipidomic profiles in patients with different lung cancer subtypes, important values of comprehensive lipidomic profiles in understanding of lung cancer heterogeneity, urgent needs of standardized methodologies, potential mechanisms by lipid-associated enzymes and proteins, and the importance of integration between clinical phenomes and lipidomic profiles. The characteristics of lipidomic profiles in different lung cancer subtypes are extremely varied among study designs, objects, methods, and analyses. Preliminary data from recent studies demonstrate the specificity of lipidomic profiles specific for lung cancer stage, severity, subtype, and response to drugs. The heterogeneity of lipidomic profiles and lipid metabolism may be part of systems heterogeneity in lung cancer and be responsible for the development of drug resistance, although there are needs for direct evidence to show the existence of intra- or inter-lung cancer heterogeneity of lipidomic profiles. With an increasing understanding of expression profiles of genes and proteins, lipidomic profiles should be associated with activities of enzymes and proteins involved in the processes of lipid metabolism, which can be profiled with genomics and proteomics, and to provide the opportunity for the integration of lipidomic profiles with gene and protein expression profiles. The concept of clinical trans-omics should be emphasized to integrate data of lipidomics with clinical phenomics to identify disease-specific and phenome-specific biomarkers and targets, although there are still a large number of challenges to be overcome in the integration between clinical phenomes and lipidomic profiles.
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