期刊
CANCER LETTERS
卷 469, 期 -, 页码 301-309出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2019.11.004
关键词
SUMOylation; Tumorigenesis
类别
资金
- National Natural Science Foundation of China [81672709]
- Science and Technology Commission of Shanghai [17DZ2260100]
Small ubiquitin-like modifier (SUMO), a critical regulatory modification protein, is involved in various biological processes, such as gene expression, genome maintenance and DNA damage repair (DDR). Numerous recent studies have revealed that disturbed SUMOylation and deSUMOylation homeostasis contribute to tumorigenesis. Abnormal alterations of key factors in the SUMO modification are closely related to cancer development and progression, indicating that the restoration of SUMOylation homeostasis may serve as a promising therapeutic strategy. In this review, we summarize the process and function of SUMOylation, clarify the 'dual-edged sword' functions of SUMOylation in diversified cancers and put forth future research prospects.
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