期刊
CANCER INVESTIGATION
卷 38, 期 4, 页码 185-208出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2020.1721523
关键词
RAS; NF-kappa B; PARP; oncogenes; cancer
类别
资金
- Institute of Nano Science and Technology (INST), Department of Science and Technology (DST), Govt. of India
Cancer is a multi-step process during which cells acquire mutations that eventually lead to uncontrolled cell growth and division and evasion of programmed cell death. The oncogenes such as Ras and c-Myc may be responsible in all three major stages of cancer i.e., early, intermediate, and late. The NF-kappa B has been shown to control the expression of genes linked with tumor pathways such as chronic inflammation, tumor cell survival, anti-apoptosis, proliferation, invasion, and angiogenesis. In the last few decades, various biomarker pathways have been identified that play a critical role in carcinogenesis such as Ras, NF-kappa B and DNA damage.
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