The Relationship Between Total Lesion Activity on 18F Choline Positron Emission Tomography-Computed Tomography and Clinical Outcome in Patients with Castration-Resistant Prostate Cancer Bone Metastases Treated with 223Radium

The aim of the study was to assess the correlation between metabolic response measured through positron emission tomography-computed tomography (PET-CT) with(18)F choline (F-18 FCH) and overall survival (OS) in patients affected by bone lesions from metastatic castration-resistant prostate cancer treated with(223)Ra dichloride. Eleven subjects were subjected to PET-CT with(18)F FCH before and 1 month after(223)Ra treatment. Reduction in total lesion activity (Delta TLA) between pretreatment and post-treatment scan was determined and patients were divided into responders (Delta TLA >50%) and nonresponders (Delta TLA <50%). The OS of the entire cohort was 12.7 +/- 3.8 months. Kaplan-Meier analysis showed that responders presented a significantly longer survival than nonresponders (16.5 +/- 1.9 months vs. 10.5 +/- 0.9 months,p < 0.05). Reduction in TLA after(223)Ra treatment seems to be correlated with a trend toward a longer survival.