期刊
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
卷 47, 期 2, 页码 226-230出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/cjn.2019.333
关键词
Alzheimer's disease; Mortality; Standardized mortality ratio; Diabetes mellitus
资金
- National Natural Science Foundation of China [81671043]
- Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20172001]
- Shanghai Education Development Foundation [16SG15]
- Shanghai Municipal Education Commission
Background: Identifying risk factors and mortality of individuals with Alzheimer's disease (AD) could have important implications for the clinical management of AD. Objective: This pilot study aimed to examine the overall mortality of AD patients over a 10-year surveillance period in Shanghai, China. This study is an extension of our previous investigation on mortality of neurodegenerative diseases. Methods: One hundred and thirty-two AD patients recruited from the memory clinics of two hospitals in Shanghai in 2007 were followed up until December 31, 2017 or death, representing a follow-up period of up to 10 years. Overall standardized mortality ratios (SMRs) were calculated, and predictors for survival at recruitment were estimated. Results: Sixty-seven patients had died by December 31, 2017, and the SMR at 10 years of follow-up was 1.225 (95% confidence interval 0.944-1.563). Employing Cox's proportional hazard modeling, lower Mini-Mental State Examination score, and comorbid diabetes predicted poor survival in this cohort. Conclusion: This pilot study suggests a similar survival trend of patients with AD compared to the general population in Shanghai urban region. Poor cognitive status and comorbid diabetes had a negative impact on the survival of AD patients.
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