期刊
CALCIFIED TISSUE INTERNATIONAL
卷 106, 期 6, 页码 616-624出版社
SPRINGER
DOI: 10.1007/s00223-020-00679-2
关键词
Epidemiology; Sarcopenia; Osteoporosis; Frailty; Muscle
资金
- National Institute on Aging (NIA) [R01AG027017, P30AG024827, T32AG021885, K07AG033174]
- Intramural Research program of the National Institutes of Health [N01AG62101, N01AG62103, N01AG62106, R01AG028050]
- National Institute of Nursing Research Grant [R01NR012459]
- Medical Research Council [MRC_MC_ UU_12011/2, MRC_MC_UP_A620_1015]
- University of Southampton, UK
- U.S. Department of Agriculture (USDA) [58-1950-4-003]
- MRC [G0400491, MC_U147585819, MC_U147585827, MC_UU_12011/2, MC_UP_A620_1015] Funding Source: UKRI
Musculoskeletal disorders are common among older people. Preventive strategies require understanding of age-related changes in strength, function and body composition, including how they interrelate. We have described, and examined associations between, 9-year changes in these parameters among 2917 Health, Aging and Body Composition Study participants (aged 70-79 years). Appendicular lean mass (ALM), whole body fat mass and total hip BMD were ascertained using DXA; muscle strength by grip dynamometry; and muscle function by gait speed. For each characteristic annualised percentage changes were calculated; measures of conditional change (independent of baseline) were derived and their interrelationships were examined using Pearson correlations; proportion of variance at 9-year follow-up explained by baseline level was estimated; and mean trajectories in relation to age were estimated using linear mixed models. Analyses were stratified by sex. Median [lower quartile, upper quartile] annual percentage declines were grip strength (1.5 [0.0, 2.9]), gait speed (2.0 [0.6, 3.7]), ALM (0.7 [0.1, 1.4]), fat mass (0.4 [- 1.1, 1.9]) and hip BMD (0.5 [0.0, 1.1]). Declines were linear for ALM and accelerated over time for other characteristics. Most conditional change measures were positively correlated, most strongly between ALM, fat mass and hip BMD (r > 0.28). Proportion of variation at follow-up explained by baseline was lower for grip strength and gait speed (39-52%) than other characteristics (69-86%). Strength and function declined more rapidly, and were less correlated between baseline and follow-up, than measures of body composition. Therefore, broader intervention strategies to prevent loss of strength and function in later life are required as those targeting body composition alone may be insufficient.
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