期刊
CALCIFIED TISSUE INTERNATIONAL
卷 109, 期 3, 页码 339-350出版社
SPRINGER
DOI: 10.1007/s00223-020-00672-9
关键词
Osteoarthritis; Nociceptive pain; DMOAD; Cartilage; Inflammation; Synovitis
资金
- Versus Arthritis Experimental Osteoarthritis Treatment Centre [20083]
- National Institute for Health Research (NIHR) through the Leeds Biomedical Research Centre
Osteoarthritis is a chronic, debilitating disease that affects millions of people worldwide, and management involves both pharmacological and non-pharmacological approaches. Traditional pharmacological treatments have limited efficacy and come with side effects, leading to the need for new therapies. Disease-modifying osteoarthritis drugs (DMOADs) show promise in improving OA symptoms.
Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients who can use them. New pharmacological therapies for managing OA are required and a number have been developed targeting different tissues in OA: bone and cartilage, synovium and nerves. However, there has been overall limited success. Disease-modifying osteoarthritis drugs (DMOADs) are a putative class of therapies aimed at improving OA structural pathologies and consequent symptoms. Recent DMOAD studies have demonstrated some promising therapies but also provided new considerations for future trials.
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