期刊
ACTA PAEDIATRICA
卷 105, 期 2, 页码 206-214出版社
WILEY
DOI: 10.1111/apa.13253
关键词
Body mass index; Child; Cow's milk; Epidemiology; Food allergy
类别
资金
- Swedish Heart and Lung Foundation
- Swedish research council
- Swedish Asthma and Allergy Foundation
- VISARE Norr
- Umea University
- Vasterbotten County Council (ALF)
- State Government funding for Health Care research (FoU)
- Jerring Foundation
- ThermoFisher Diagnostics, Uppsala, Sweden
Aim: We investigated phenotypes of milk hypersensitivity among schoolchildren aged 11-12 in Northern Sweden. Methods: In a population-based cohort, 1824 (98%) children aged 11-12 participated in a questionnaire survey, skin prick testing, interviews on food hypersensitivity and assessment of body mass index (BMI). Of the 265 children reporting milk hypersensitivity, milk avoidance and no coeliac disease, 236 (89%) participated in a structured interview and blood samples for analyses of milk-specific Immunoglobulin E. The children were then categorised into milk hypersensitivity phenotypes according to preset criteria. Results: In all, 14.5% reported milk hypersensitivity. Of these, 3% were categorised as current milk allergy, 23% as outgrown milk allergy, 40% as probable lactose intolerance and 11% as nondefinable. Furthermore, 23% had discontinued their elimination diet. Milk allergy was associated with other atopic disorders and lower BMI, with an odds ratio of 0.82 and 95% confidence interval of 0.80-0.98. Only 2% had previously undergone an oral challenge. Conclusion: The most common symptom phenotypes among Swedish children aged 11-12 with self-reported milk hypersensitivity and milk avoidance were probable intolerance and outgrown milk allergy, while current milk allergy was uncommon. Children with milk allergy had a lower BMI and most lacked a challenge-proven diagnosis.
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