期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 189, 期 5, 页码 904-907出版社
WILEY
DOI: 10.1111/bjh.16443
关键词
multiple myeloma; mass spectrometry; flow cytometry
类别
资金
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
- Memorial Sloan Kettering Core Funding Source: Medline
- Society of Memorial Sloan Kettering Funding Source: Medline
Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) may soon replace routine electrophoretic methods for monitoring monoclonal proteins in patients with multiple myeloma. To further evaluate the clinical utility of this assay, we compared the performance of MALDI-TOF-MS head-to-head with an established bone marrow-based measurable residual disease assay by flow cytometry (Flow-BM-MRD), using Memorial Sloan Kettering Cancer Center's 10-color, single-tube method. Our results suggest that MALDI-TOF-MS adds value to bone marrow-based MRD testing and may be most useful for early detection of relapse in peripheral blood compared to current electrophoretic methods.
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