期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 189, 期 2, 页码 318-322出版社
WILEY
DOI: 10.1111/bjh.16336
关键词
large granular lymphocytic leukaemia; solid organ transplantation; bone marrow transplantation
类别
资金
- NHLBI NIH HHS [R01 HL132071, R35 HL135795, R01 HL123904, R01 HL118281] Funding Source: Medline
- NIH HHS Funding Source: Medline
T-cell large granular lymphocytic leukaemia (T-LGLL) is a chronic clonal lymphoproliferative disorder of cytotoxic T lymphocytes which commonly occurs in older patients and is often associated with autoimmune diseases. Among 246 patients with T-LGLL seen at our institution over the last 10 years, we encountered 15 cases following solid organ or haematopoietic stem cell transplantation. Here, we studied the clinical characterization of these cases and compared them to de novo T-LGLL. This experience represented a clear picture of the intricate nature of the disease manifestation and the complexities of several immune mechanisms triggering the clonal expansion.
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