期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 189, 期 3, 页码 513-517出版社
WILEY
DOI: 10.1111/bjh.16270
关键词
acute lymphpoblastic leukaemia; central nervous system; cerebral spinal fluid; cell death; cell adhesion
类别
资金
- Children's Cancer Research Fund
- American Cancer Society
- NIH [T32 CA099936]
- Timothy O'Connell Foundation
Central nervous system (CNS) relapse is a common cause of treatment failure in patients with acute lymphoblastic leukaemia (ALL) despite current CNS-directed therapies that are also associated with significant short- and long-term toxicities. Herein, we showed that leukaemia cells exhibit decreased proliferation, elevated reactive oxygen species (ROS) and increased cell death in cerebral spinal fluid (CSF) both in vitro and in vivo. However, interactions between leukaemia and meningeal cells mitigated these adverse effects. This work expands our understanding of the pathophysiology of CNS leukaemia and suggests novel therapeutic approaches for more effectively targeting leukaemia cells in the CNS.
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