期刊
BRAIN RESEARCH
卷 1730, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.brainres.2019.146642
关键词
Parkinson's disease; Usnic acid; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Neuroinflammation; Anti-inflammation
资金
- National Research Foundation of Korea (NRF), South Korea [2018R1D1A1B07043493, 2019H1A2A1076083]
- National Research Foundation of Korea [2019H1A2A1076083, 2018R1D1A1B07043493] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Neuroinflammation is often associated with astrocyte and microglial activations particularly in Parkinson's disease (PD) and other brain damage such as Alzheimer's disease. Therefore, the modulation of glial activation offers a possible target for treating PD-associated pathologies. Here, we evaluated the neuroprotective effects of usnic acid, a naturally occurring dibenzofuran derivative found in several lichen species in an acute mouse model of PD. Male mice were administered with vehicle or usnic acid (5 or 25 mg/kg) for 10 consecutive days, and then on day 11, MPTP (20 mg/kg, i.p.) was administered four times (with 2 hrs intervals between injections) to induce PD pathologies. It was found that MPTP-induced motor dysfunction and neuronal loss were ameliorated in the usnic acid-treated mice versus vehicle-treated controls. Further study revealed that usnic acid effectively inhibited MPP +-induced glial activation in primary astrocytes by blocking NF-kappa B activation. Taken together, these findings suggest that usnic acid could be considered potentially useful therapeutic candidates for PD and other neurodegenerative diseases associated with neuroinflammation.
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